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Mitochondrial fission can be roughly divided into three steps, as follows: Drp1 protein is recruited from the cytoplasm and transferred to the outer mitochondrial membrane for oligomerization (Frohlich et al., 2013), which depends on its GTPase activity

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Moreover, most of the existing preclinical studies have relied on male rodents, neglecting sex-specific variants in gut microbiota compositions and neuroinflammatory responses (Lu et al., 2024)